Please use this identifier to cite or link to this item:
|Title:||Nutrients Induce Different Ca2+ Signals in Cytosol and Nucleus in Pancreatic β-Cells|
|Source:||Quesada, I., Martin, F., Roche, E., Soria, B. (2004-02). Nutrients Induce Different Ca2+ Signals in Cytosol and Nucleus in Pancreatic β-Cells. Diabetes 53 (SUPPL. 1) : S92-S95. ScholarBank@NUS Repository. https://doi.org/10.2337/diabetes.53.suppl_3.S92|
|Abstract:||Specific activation of Ca2+-dependent functions is achieved by the particular dynamics and local restriction of Ca2+ signals. It has been shown that changes in amplitude, duration, or frequency of Ca 2+ signals modulate gene transcription. Thus, Ca2+ variations should be finely controlled within the nucleus. Although a variety of mechanisms in the nuclear membrane have been demonstrated to regulate nuclear Ca2+, the existence of an autonomous Ca2+ homeostasis within the nucleus is still questioned. In the pancreatic β-cell, besides their effect on insulin secretion, Ca2+ messages generated by nutrients also exert their action on gene expression. However, the dynamics of these Ca2+ signals in relation to nuclear function have been explored little in islet cells. In the current study, Ca 2+ changes both in the nucleoplasm and in the cytosol of INS-1 and pancreatic β-cells were monitored using spot confocal microscopy. We show that nutrients trigger Ca2+ signals of higher amplitude in the nucleus than in the cytosol. These amplitude-modulated Ca2+ signals transmitted to the nucleus might play an important role in the control of gene expression in the pancreatic β-cell.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 27, 2018
WEB OF SCIENCETM
checked on Feb 14, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.