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|Title:||Haplotypes of the β2-adrenergic receptor gene are associated with essential hypertension in a Singaporean Chinese population|
|Citation:||Lee, Y.-W., Oh, V.M.S., Garcia, E., Taylor, E.A., Wu, H., Yap, E.P.H., Kazeem, G.R., Caulfield, M.J., Munroe, P.B. (2004-11). Haplotypes of the β2-adrenergic receptor gene are associated with essential hypertension in a Singaporean Chinese population. Journal of Hypertension 22 (11) : 2111-2116. ScholarBank@NUS Repository. https://doi.org/10.1097/00004872-200411000-00012|
|Abstract:||Objective: To investigate the relation between the gene encoding the β2-adrenergic receptor (B2AR) and essential hypertension in a Singaporean Chinese cohort. Methods: Three single nucleotide polymorphisms (SNPs) were genotyped in 190 cases and 323 controls, and eight haplotypes were determined and tested for association using the likelihood test statistic. Results: We observed a significant difference in haplotype frequency distributions between the cases and the controls (P<0.00001). A logistic regression model fitted to the data supported this finding. Conclusion: The results suggest that variants at the B2AR locus may play a role in the pathophysiology of hypertension in this population. © 2004 Lippincott Williams & Wilkins.|
|Source Title:||Journal of Hypertension|
|Appears in Collections:||Staff Publications|
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