Please use this identifier to cite or link to this item: https://doi.org/10.1097/00004872-200411000-00012
Title: Haplotypes of the β2-adrenergic receptor gene are associated with essential hypertension in a Singaporean Chinese population
Authors: Lee, Y.-W.
Oh, V.M.S. 
Garcia, E.
Taylor, E.A.
Wu, H.
Yap, E.P.H.
Kazeem, G.R.
Caulfield, M.J.
Munroe, P.B.
Keywords: β2-adrenergic receptor
Chinese
Haplotypes
Primary hypertension
Singapore
Issue Date: Nov-2004
Citation: Lee, Y.-W., Oh, V.M.S., Garcia, E., Taylor, E.A., Wu, H., Yap, E.P.H., Kazeem, G.R., Caulfield, M.J., Munroe, P.B. (2004-11). Haplotypes of the β2-adrenergic receptor gene are associated with essential hypertension in a Singaporean Chinese population. Journal of Hypertension 22 (11) : 2111-2116. ScholarBank@NUS Repository. https://doi.org/10.1097/00004872-200411000-00012
Abstract: Objective: To investigate the relation between the gene encoding the β2-adrenergic receptor (B2AR) and essential hypertension in a Singaporean Chinese cohort. Methods: Three single nucleotide polymorphisms (SNPs) were genotyped in 190 cases and 323 controls, and eight haplotypes were determined and tested for association using the likelihood test statistic. Results: We observed a significant difference in haplotype frequency distributions between the cases and the controls (P<0.00001). A logistic regression model fitted to the data supported this finding. Conclusion: The results suggest that variants at the B2AR locus may play a role in the pathophysiology of hypertension in this population. © 2004 Lippincott Williams & Wilkins.
Source Title: Journal of Hypertension
URI: http://scholarbank.nus.edu.sg/handle/10635/108095
ISSN: 02636352
DOI: 10.1097/00004872-200411000-00012
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