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https://doi.org/10.1016/S0014-2999(03)01997-6
DC Field | Value | |
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dc.title | Herbimycin A attenuates apoptosis during heat stress in rats | |
dc.contributor.author | Sachidhanandam, S.B. | |
dc.contributor.author | Lu, J. | |
dc.contributor.author | Low, K.S.Y. | |
dc.contributor.author | Moochhala, S.M. | |
dc.date.accessioned | 2014-11-20T05:58:49Z | |
dc.date.available | 2014-11-20T05:58:49Z | |
dc.date.issued | 2003-08-01 | |
dc.identifier.citation | Sachidhanandam, S.B., Lu, J., Low, K.S.Y., Moochhala, S.M. (2003-08-01). Herbimycin A attenuates apoptosis during heat stress in rats. European Journal of Pharmacology 474 (1) : 121-128. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-2999(03)01997-6 | |
dc.identifier.issn | 00142999 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/108094 | |
dc.description.abstract | Expression of heat shock proteins (HSPs) as a heat stress response is associated with acquisition of thermotolerance. Herbimycin A is a tyrosine kinase inhibitor that has been shown to induce HSPs. The present study aims to investigate the effects of herbimycin A on thermotolerance in rats subjected to heat stress exposure. Herbimycin A induced hsp70 to peak levels 12 h post-injection in rats without heat stress. No change in hsp70 levels was observed in the vehicle- and saline-treated rats. In rats exposed to heat stress at 45 °C for 25 min, 12 h post-treatment, lower peak temperatures were attained in herbimycin A-treated group as compared to the vehicle- and saline-treated groups. Terminal transferase-mediated d-UTP nick end labeling (TUNEL) showed that a significant decrease in apoptosis of hepatocytes in herbimycin A-treated rats as compared to the vehicle- and saline-treated rats. Caspase-3 activation was also lower in herbimycin A-treated rats, compared to the vehicle- and saline-treated rats. The present study has demonstrated that herbimycin A is effective for development of thermotolerance and therefore protects rats from heat stress. © 2003 Elsevier B.V. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-2999(03)01997-6 | |
dc.source | Scopus | |
dc.subject | (Rat) | |
dc.subject | Apoptosis | |
dc.subject | Heat shock protein | |
dc.subject | Herbimycin A | |
dc.subject | Thermotolerance | |
dc.type | Article | |
dc.contributor.department | PHARMACOLOGY | |
dc.contributor.department | ANATOMY | |
dc.description.doi | 10.1016/S0014-2999(03)01997-6 | |
dc.description.sourcetitle | European Journal of Pharmacology | |
dc.description.volume | 474 | |
dc.description.issue | 1 | |
dc.description.page | 121-128 | |
dc.description.coden | EJPHA | |
dc.identifier.isiut | 000184819000015 | |
Appears in Collections: | Staff Publications |
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