Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/108085
DC Field | Value | |
---|---|---|
dc.title | Production of monoclonal antibodies against human hepatocellular carcinoma by immunisation with a cell membrane preparation. | |
dc.contributor.author | Tan, L.S. | |
dc.date.accessioned | 2014-11-20T05:58:43Z | |
dc.date.available | 2014-11-20T05:58:43Z | |
dc.date.issued | 1990-03 | |
dc.identifier.citation | Tan, L.S. (1990-03). Production of monoclonal antibodies against human hepatocellular carcinoma by immunisation with a cell membrane preparation.. Annals of the Academy of Medicine Singapore 19 (2) : 147-151. ScholarBank@NUS Repository. | |
dc.identifier.issn | 03044602 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/108085 | |
dc.description.abstract | Monoclonal antibodies that bound to 3 human hepatocellular carcinoma cell lines (PLC/PRF/5, SK-SF and Mahlavu) and snap-frozen sections of a patient's tumour were raised by immunising mice with PLC/PRF/5 membrane preparations. The monoclonals designated RF-HCC 1 and RF-HCC 2 were of IgG1 and IgM subclasses respectively. Binding of the antibodies to surface epitopes present on Mahlavu cells in vitro took place in a biphasic fashion, with initial rapid binding of each antibody during the first 15 minutes of incubation followed by a plateau after this period. It was found that the commercially available MOPC 21 myeloma IgG1 (Sigma) monoclonal antibody used a control also bound to a surface antigenic determinant expressed on Mahlavu cells. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.sourcetitle | Annals of the Academy of Medicine Singapore | |
dc.description.volume | 19 | |
dc.description.issue | 2 | |
dc.description.page | 147-151 | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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