Please use this identifier to cite or link to this item: https://doi.org/10.1097/00008571-199510000-00010
Title: Glutathione S transferase-θ (GSTT1) genetic polymorphism among Chinese, Malays and Indians in Singapore
Authors: Lee, E.J.D. 
Wong, J.Y.Y.
Yeoh, P.N.
Gong, N.H.
Keywords: Chinese
GSTT1
Indians
Malays
Polymorphism
Issue Date: 1995
Source: Lee, E.J.D., Wong, J.Y.Y., Yeoh, P.N., Gong, N.H. (1995). Glutathione S transferase-θ (GSTT1) genetic polymorphism among Chinese, Malays and Indians in Singapore. Pharmacogenetics 5 (5) : 332-334. ScholarBank@NUS Repository. https://doi.org/10.1097/00008571-199510000-00010
Abstract: Glutathione S-transferase-θ (GSTT1) is subject to a genetic polymorphism where approximately 50% of a Caucasian population are homozygous for the null allele. Because of the possible association of the polymorphism with increased cancer risk in individuals, we genotyped by polymerase chain reaction 187 normal Chinese, 167 normal Malays and 152 normal Indians from Singapore and Malaysia. The proportion of Chinese, Malays and Indians with the null genotype were 58%, 38% and 16% respectively and mirrored previously reported frequencies of the GSTM1 null genotype in these populations. The frequency of the combined GSTM1 and GSTT1 null genotypes among Chinese, Malays and Indians were 37%, 22% and 5% respectively. The similarity with predicted frequencies indicated no interaction between the two genetic polymorphisms.
Source Title: Pharmacogenetics
URI: http://scholarbank.nus.edu.sg/handle/10635/108079
ISSN: 0960314X
DOI: 10.1097/00008571-199510000-00010
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