Please use this identifier to cite or link to this item:
|Title:||Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia|
Oi-Mei Chan, A.
Polymerase chain reaction
|Citation:||Chong, S.-A., Lee, W.-L., Tan, C.-H., Hou-NgeeTay, A., Oi-Mei Chan, A., Tan, E.-C. (2000-12-27). Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia. Psychiatry Research 97 (2-3) : 101-106. ScholarBank@NUS Repository. https://doi.org/10.1016/S0165-1781(00)00229-8|
|Abstract:||Abnormalities of serotonin synthesis and metabolism may be associated with suicidality. The serotonin transporter gene (5-HTT) is one of the important genes involved in the regulation of serotonin neurotransmission. We examined the association of suicidal behavior in Chinese schizophrenic patients with a functional polymorphism of the promoter region of the 5-HTT gene (5-HTTLPR). The 5-HTTLPR genotype was determined by polymerase chain reaction for 76 suicidal and 262 non-suicidal patients with a diagnosis of schizophrenia (DSM-IV criteria). All subjects were unrelated to each other, and all were Chinese. There was no significant genotypic or allelic association of the 5-HTTLPR polymorphism with history of attempted suicide. From our results, this 5-HTTLPR polymorphism is unlikely to have a major effect on suicidal behavior in Chinese patients with schizophrenia. © 2000 Elsevier Science Ltd.|
|Source Title:||Psychiatry Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 18, 2019
WEB OF SCIENCETM
checked on Feb 11, 2019
checked on Feb 8, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.