Please use this identifier to cite or link to this item: https://doi.org/10.1097/00001756-200307180-00002
Title: Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients
Authors: Tsang, S.W.Y. 
Lai, M.K.P.
Francis, P.T.
Wong, P.T.-H. 
Spence, I.
Esiri, M.M.
Keene, J.
Hope, T.
Chen, C.P.L.-H.
Keywords: Alzheimer's disease
Anxiety
Neocortex
Polymorphisms
Serotonin transporter
Issue Date: 18-Jul-2003
Citation: Tsang, S.W.Y., Lai, M.K.P., Francis, P.T., Wong, P.T.-H., Spence, I., Esiri, M.M., Keene, J., Hope, T., Chen, C.P.L.-H. (2003-07-18). Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients. NeuroReport 14 (10) : 1297-1300. ScholarBank@NUS Repository. https://doi.org/10.1097/00001756-200307180-00002
Abstract: Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTTsites in the temporal cortex of AD patients with prominent antemortem anxiety were unaltered compared with controls, but were reduced in non-anxious AD subjects. Furthermore, homozygosity for the high activity allele of a functional polymorphism in the 5-HTT gene promoter region (5-HTTLPR) was associated with both increased [3H]citalopram binding and occurrence of anxiety in the AD subjects. Since serotonin-synthesizing neurons are known to be lost in the AD cortex, this study suggests that the preservation of 5-HTT may exacerbate serotonergic deficits and underlie anxiety symptoms in AD. © 2003 Lippincott Williams & Wilkins.
Source Title: NeuroReport
URI: http://scholarbank.nus.edu.sg/handle/10635/108066
ISSN: 09594965
DOI: 10.1097/00001756-200307180-00002
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