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|Title:||Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients|
|Authors:||Tsang, S.W.Y. |
|Source:||Tsang, S.W.Y., Lai, M.K.P., Francis, P.T., Wong, P.T.-H., Spence, I., Esiri, M.M., Keene, J., Hope, T., Chen, C.P.L.-H. (2003-07-18). Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients. NeuroReport 14 (10) : 1297-1300. ScholarBank@NUS Repository. https://doi.org/10.1097/00001756-200307180-00002|
|Abstract:||Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTTsites in the temporal cortex of AD patients with prominent antemortem anxiety were unaltered compared with controls, but were reduced in non-anxious AD subjects. Furthermore, homozygosity for the high activity allele of a functional polymorphism in the 5-HTT gene promoter region (5-HTTLPR) was associated with both increased [3H]citalopram binding and occurrence of anxiety in the AD subjects. Since serotonin-synthesizing neurons are known to be lost in the AD cortex, this study suggests that the preservation of 5-HTT may exacerbate serotonergic deficits and underlie anxiety symptoms in AD. © 2003 Lippincott Williams & Wilkins.|
|Appears in Collections:||Staff Publications|
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