Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/108064
Title: Chronic all-trans retinoic acid treatment prevents medial thickening of intramyocardial and intrarenal arteries in spontaneously hypertensive rats
Authors: Lü, L.
Yao, T.
Zhu, Y.-Z. 
Huang, G.-Y.
Cao, Y.-X.
Zhu, Y.-C.
Keywords: Hypertension
Myocardial hypertrophy
Ventricular fibrosis
Issue Date: 1-Oct-2003
Source: Lü, L.,Yao, T.,Zhu, Y.-Z.,Huang, G.-Y.,Cao, Y.-X.,Zhu, Y.-C. (2003-10-01). Chronic all-trans retinoic acid treatment prevents medial thickening of intramyocardial and intrarenal arteries in spontaneously hypertensive rats. American Journal of Physiology - Heart and Circulatory Physiology 285 (4 54-4) : H1370-H1377. ScholarBank@NUS Repository.
Abstract: There are in vitro data linking all-trans retinoic acid (atRA) with inhibition of hypertrophy and hyperplasia in cardiomyocytes, vascular smooth muscle cells, and fibroblasts. In the present study, we tested the hypothesis that chronic treatment with atRA may blunt the process of myocardial remodeling in spontanously hypertensive rats (SHR). Four-week-old male SHR were treated with atRA (5 or 10 mg·kg -1·day -1) given daily for 3 mo by gavage; age- and sex-matched Wistar-Kyoto rats (WKY) and placebo-treated SHR served as controls. At the end of the treatment period, cardiac geometry and function were assessed by Doppler echocardiography. Histological examination and RIA were performed to evaluate medial thickening of intramyocardial and renal arteries, perivascular and interstitial collagen content, and atrial natriuretic peptide (ANP) and IGF-I in the heart, respectively. The novel finding of the present study is that atRA prevented hypertrophy of intramyocardial and intrarenal arteries and ventricular fibrosis. However, atRA treatment did not lower blood pressure or left ventricular weight and left ventricular weight-to-body weight ratio in SHR. atRA did not change cardiac geometry and function as assessed by Doppler echocardiography. atRA showed no influence on either ANP or IGF-I levels. In conclusion, the present study suggests that chronic atRA treatment prevents medial thickening of intramyocardial and intrarenal arteries and ventricular fibrosis during the development of hypertension. Left ventricular hypertrophy and cardiac geometry and function are not changed by atRA treatment.
Source Title: American Journal of Physiology - Heart and Circulatory Physiology
URI: http://scholarbank.nus.edu.sg/handle/10635/108064
ISSN: 03636135
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

15
checked on Feb 16, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.