Please use this identifier to cite or link to this item:
|Title:||Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat|
|Authors:||Bhatia, M. |
|Source:||Bhatia, M., Sidhapuriwala, J., Moochhala, S.M., Moore, P.K. (2005-05). Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. British Journal of Pharmacology 145 (2) : 141-144. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjp.0706186|
|Abstract:||Hydrogen sulphide (H 2S) is a naturally occurring gas, with potent vasodilator activity. In this report, we identify a role for H 2S in carrageenan-induced hindpaw oedema in the rat. Intraplantar injection of carrageenan (150 μl, 2% (w v -1)) resulted in an increase in hindpaw H 2S synthesising enzyme activity and increased myeloperoxidase (MPO) activity. Pretreatment (i.p. 60 min before carrageenan) with DL-propargylglycine (PAG, 25-75 mg kg -1), an inhibitor of the H2S synthesising enzyme cystathionine-γ-lyase (CSE), significantly reduced carrageenan-induced hindpaw oedema in a dose-dependent manner (e.g. increase in hindpaw weight at 3h, saline: 0.12 ± 0.017 g; carrageenan, 1.39 ± 0.037 g; PAG, 50 mg kg -1, 1.11 ± 0.06 g, n = 10) and MPO activity (fold increase) in the hindpaw (saline: 1.0 ± 0.12; carrageenan, 2.92 ± 0.45g; PAG, 50 mg kg -1, 1.1 ± 0.22, n = 10); PAG (50 mg kg -1) also inhibited H 2S synthesising enzyme activity (nmol μg DNA -1) in the hindpaw in a dose-dependent manner (saline, 0.46 ± 0.05; carrageenan, 0.71 ± 0.08 g; PAG, 50 mg kg -1, 0.17 ± 0.05, n = 10). © 2005 Nature Publishing Group. All rights reserved.|
|Source Title:||British Journal of Pharmacology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 13, 2017
WEB OF SCIENCETM
checked on Nov 16, 2017
checked on Dec 10, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.