Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/107995
Title: Effects of genistein on ATP induced DNA synthesis and intracellular alkalinization in Chang liver cells
Authors: Sit, K.-H. 
Wong, K.-P. 
Bay, B.-H. 
Issue Date: 1991
Source: Sit, K.-H.,Wong, K.-P.,Bay, B.-H. (1991). Effects of genistein on ATP induced DNA synthesis and intracellular alkalinization in Chang liver cells. Japanese Journal of Pharmacology 57 (1) : 109-111. ScholarBank@NUS Repository.
Abstract: Extracellular ATP (adenosine 5'-triphosphate) produces a dose-dependent elevation of DNA synthesis concomitantly with raised intracellular pH (pH(i)) in quiescent monolayer Chang liver cells; Genistein produces a dose-dependent suppression of ATP-induced DNA synthesis without affecting cell viability (dead cell index ≃ 5%) or pH(i) elevation. The results suggest that (a) mitogenesis and pH(i) are not imperative correlates and (b) genistein is effective in inhibiting DNA synthesis whether due to growth factor or ″non-growth factor″ stimulation.
Source Title: Japanese Journal of Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/107995
ISSN: 00215198
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

21
checked on Dec 14, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.