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|Title:||Effects of genistein on ATP induced DNA synthesis and intracellular alkalinization in Chang liver cells|
|Authors:||Sit, K.-H. |
|Citation:||Sit, K.-H.,Wong, K.-P.,Bay, B.-H. (1991). Effects of genistein on ATP induced DNA synthesis and intracellular alkalinization in Chang liver cells. Japanese Journal of Pharmacology 57 (1) : 109-111. ScholarBank@NUS Repository.|
|Abstract:||Extracellular ATP (adenosine 5'-triphosphate) produces a dose-dependent elevation of DNA synthesis concomitantly with raised intracellular pH (pH(i)) in quiescent monolayer Chang liver cells; Genistein produces a dose-dependent suppression of ATP-induced DNA synthesis without affecting cell viability (dead cell index ≃ 5%) or pH(i) elevation. The results suggest that (a) mitogenesis and pH(i) are not imperative correlates and (b) genistein is effective in inhibiting DNA synthesis whether due to growth factor or ″non-growth factor″ stimulation.|
|Source Title:||Japanese Journal of Pharmacology|
|Appears in Collections:||Staff Publications|
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