Please use this identifier to cite or link to this item: https://doi.org/10.1097/DAD.0b013e3181c03402
Title: Atypical cellular unguioblastic fibroma - A rare case with more atypical histological features than previously reported
Authors: Petersson, F.
Tang, A.L.Y.
Jin, A.C.E.
Barr, R.J.
Lee, V.K. 
Keywords: Atypical
Immunohistochemistry
Onychomatricoma
Unguioblastic fibroma
Unguioblastoma
Issue Date: Jun-2010
Citation: Petersson, F., Tang, A.L.Y., Jin, A.C.E., Barr, R.J., Lee, V.K. (2010-06). Atypical cellular unguioblastic fibroma - A rare case with more atypical histological features than previously reported. American Journal of Dermatopathology 32 (4) : 387-391. ScholarBank@NUS Repository. https://doi.org/10.1097/DAD.0b013e3181c03402
Abstract: We herein present the clinicopathological features of an atypical cellular unguioblastic fibroma, a rare onychomatrical tumor, in an adult woman of Southeast Asian origin. The tumor displayed both diffuse hypercellularity and atypia in the mesenchymal component and the presence of large multinucleated cells with a ring-/floret-like arrangement of irregular and hyperchromatic nuclei. The mesenchymal cells displayed a patchy weak positive immunereactivity for CD34 (including atypical and wreath-like multinucleated cells) and for CD10 but were negative for low molecular weight cytokeratins, epithelial membrane antigen, CD68, factor XIIIa, smooth muscle actin, desmin, and HMB-45. The proliferative index as measured immunohistochemically (Mib-1/Ki-67) was 5%. The extent of these atypical histological features has not previously been described. One-year follow-up has been uneventful. Copyright © 2010 by Lippincott Williams & Wilkins.
Source Title: American Journal of Dermatopathology
URI: http://scholarbank.nus.edu.sg/handle/10635/107937
ISSN: 01931091
DOI: 10.1097/DAD.0b013e3181c03402
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