Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/107797
Title: Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies
Authors: Halliwell, B. 
Keywords: Antioxidants
Hydroxyl radical
Nitric oxide
Oxidative DNA damage
Peroxynitrite
Reactive oxygen/chlorine/nitrogen species
Singlet oxygen
Issue Date: 1998
Citation: Halliwell, B. (1998). Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies. Free Radical Research 29 (6) : 469-486. ScholarBank@NUS Repository.
Abstract: Damage to DNA by oxygen radicals and other reactive oxygen/nitrogen/chlorine species occurs in vivo despite the presence of multiple antioxidant defence and repair systems. Such damage is thought to make a significant contribution to the age-related development of cancer. Modulation of oxidative DNA damage by diet thus constitutes a 'biomarker' putatively predictive of the effect of diet on cancer incidence, provided that DNA damage can be accurately quantitated by validated methods. Current issues addressed in this article include the problems of artifactual DNA oxidation during isolation and analysis, the relative merits of different analytical methods, the advantages and disadvantages of relying on measurement of 8-hydroxy deoxyganosine (8OHdG, 8-oxodG) as an index of oxidative DNA damage, and the limited data that are so far available on how diet can affect 'steady-state' levels of oxidative DNA damage in humans. It appears that such damage can be modulated by vegetable intake, although the effects of vegetables may be mediated by components different from the 'classical' antioxidants vitamin C, α-tocopherol and β-carotene.
Source Title: Free Radical Research
URI: http://scholarbank.nus.edu.sg/handle/10635/107797
ISSN: 10715762
Appears in Collections:Staff Publications

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