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Title: Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease
Authors: Fang, L.
Wei, H.
Mak, K.H.
Xiong, Z.
Song, J.
Wang, D.
Lim, Y.L.
Chatterjee, S. 
Keywords: C-reactive protein
Cell adhesion molecules
Coronary artery disease
White blood cell count
Issue Date: Dec-2004
Source: Fang, L.,Wei, H.,Mak, K.H.,Xiong, Z.,Song, J.,Wang, D.,Lim, Y.L.,Chatterjee, S. (2004-12). Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease. Canadian Journal of Cardiology 20 (14) : 1433-1438. ScholarBank@NUS Repository.
Abstract: Background: Inflammation plays an important role in atherosclerosis. Markers of low-grade chronic inflammation, such as C-reactive protein (CRP) and soluble cell adhesion molecules (sCAMs), have been associated with coronary artery disease (CAD). Objective: To evaluate the significance of inflammatory markers as novel risk factors for CAD in the Chinese population. Methods: High-sensitivity CRP (hs-CRP); sCAMs, including vascular cell adhesion molecule-1 (sVCAM-1), intercellular cell adhesion molecule-1 (sICAM-1), P-selectin (sP-selectin) and E-selectin (sE-selectin); and white blood cell (WBC) count were measured in 170 angiographically defined CAD patients (70% or greater stenosis affecting at least one vessel) and 177 healthy control subjects in the Chinese population in Singapore. Results: The levels of Hs-CRP, sVCAM-1 and sP-selectin, and the WBC count were higher in CAD patients than in control subjects (P<0.001, P<0.05, P<0.05 and P<0.001, respectively). There were no significant differences in the levels of sICAM-1 and sE-selectin between the two groups. Patients with unstable angina or myocardial infarction had higher levels of hs-CRP, and higher WBC and monocyte counts than those with stable angina or atypical chest pain (all P<0.05). The level of sP-selectin in patients with multivessel disease was higher than in those with single-vessel disease (P<0.05). Overall, the levels of hs-CRP and sCAMs showed a significant correlation with the lipid profile and the WBC count. Conclusion: The present study suggests that inflammatory markers, including hs-CRP and WBC count, together with sP-selectin and sVCAM-1, could serve as markers of atherogenesis in Chinese patients with CAD, with potential diagnostic and therapeutic implications. ©2004 Pulsus Group Inc. All rights reserved.
Source Title: Canadian Journal of Cardiology
ISSN: 0828282X
Appears in Collections:Staff Publications

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