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|Title:||Brain phenolsulfotransferase (PST) activity in spontaneously hypertensive and normotensive rats|
|Source:||Mok, J.S.L.,Hutchinson, J.S.,Wong, K.P. (1990). Brain phenolsulfotransferase (PST) activity in spontaneously hypertensive and normotensive rats. Biogenic Amines 7 (5) : 475-481. ScholarBank@NUS Repository.|
|Abstract:||Phenolsulfotransferase (PST, EC 126.96.36.199) activity was measured with dopamine as substrate in homogenates of different brain areas in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Dopamine 35sulfate so formed was separated from the sulfate donor, 3'-phosphoadenosine-5'-phosphosulfate (PAP 35S) by paper chromatography and quantitated by liquid scintillation counting. The four brain regions examined, namely the hypothalamus, striatum, cortex and brain stem showed marked regional variations of PST activity with the highest value in the hypothalamus. The PST activities in these brain areas of SHR were not significantly different from the corresponding values in normotensive WKY controls. From this study, it would appear that the PST activity in the rat brain does not play a role in the pathogenesis and/or maintenance of hypertension in SHR.|
|Source Title:||Biogenic Amines|
|Appears in Collections:||Staff Publications|
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