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|Title:||IL-4 in tuberculosis: Implications for vaccine design|
Teng Seah, G.
|Citation:||Rook, G.A.W., Hernandez-Pando, R., Dheda, K., Teng Seah, G. (2004-09). IL-4 in tuberculosis: Implications for vaccine design. Trends in Immunology 25 (9) : 483-488. ScholarBank@NUS Repository.|
|Abstract:||Current attempts to find a vaccine for tuberculosis (TB) are based on the assumption that it must drive a Th1 response. We review the evidence that progressive disease might not be due to absence of Th1, but rather to the subversive effect of an unusual Th2-like response, involving interleukin-4 (IL-4) and IL-4δ2. This Th2-like response can impair bactericidal function and lead to toxicity of tumour necrosis factor-α (TNF-α) and to pulmonary fibrosis. If this is important, effective vaccines will need to suppress pre-existing Th2-like activity. Such vaccines are feasible and are active therapeutically in mouse TB.|
|Source Title:||Trends in Immunology|
|Appears in Collections:||Staff Publications|
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