Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/107686
Title: Distributions of exons and introns in the human genome
Authors: Sakharkar, M.K. 
Chow, V.T.K. 
Kangueane, P.
Keywords: Architecture
Average
Chromosome
Correlation
Distributions
DNA
Exon
Gene
Gene evolution
Gene structure
Genome
Genome evolution
Genomics
Human
Intron
Length
Non-coding DNA
Profile
Size
Issue Date: 2004
Source: Sakharkar, M.K.,Chow, V.T.K.,Kangueane, P. (2004). Distributions of exons and introns in the human genome. In Silico Biology 4 (4) : 387-393. ScholarBank@NUS Repository.
Abstract: The human genome is revisited using exon and intron distribution profiles. The 26,564 annotated genes in the human genome (build October, 2003) contain 233,785 exons and 207,344 introns. On average, there are 8.8 exons and 7.8 introns per gene. About 80% of the exons on each chromosome are < 200 bp in length. < 0.01% of the introns are < 20 bp in length and < 10% of introns are more than 11,000 bp in length. These results suggest constraints on the splicing machinery to splice out very long or very short introns and provide insight to optimal intron length selection. Interestingly, the total length in introns and intergenic DNA on each chromosome is significantly correlated to the determined chromosome size with a coefficient of correlation r = 0.95 and r = 0.97, respectively. These results suggest their implication in genome design. © 2004 - IOS Press and Bioinformation Systems e V. and all the authors. All rights reserved.
Source Title: In Silico Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/107686
ISSN: 13866338
Appears in Collections:Staff Publications

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