Please use this identifier to cite or link to this item: https://doi.org/10.1002/jmv.2037
Title: MIP-1α and MIP-1β induction by dengue virus
Authors: Lok, S.M.
Ng, M.L. 
Aaskov, J.
Keywords: Chemokine
Fever
Hemorrhagic
Macrophage
Monocyte
Issue Date: 2001
Source: Lok, S.M., Ng, M.L., Aaskov, J. (2001). MIP-1α and MIP-1β induction by dengue virus. Journal of Medical Virology 65 (2) : 324-330. ScholarBank@NUS Repository. https://doi.org/10.1002/jmv.2037
Abstract: Dengue virus (DV) infection can result in either a mild febrile illness known as dengue fever (DF) or a life-threatening disease called dengue hemorrhagic fever (DHF). DHF is more prevalent in patients undergoing secondary DV infection. This observation has led to the hypothesis that DHF may be the result of immune reactions to the secondary DV infection; an event termed immunopathology. Two cellular factors, MIP-1α and MIP-1β, have been found to be induced by infection with DV. MIP-1 induction by DV infection was observed in a myelomonocytic cell line, as well as in peripheral blood mononuclear cells isolated from a dengue naive donor. MIP-1 induction was not due to factors secreted by infected cells. In fact, replication-competent virus was required to induce MIP-1. Evidence is also provided that MIP-1 genes are expressed in patients with dengue disease. It is hypothesized that these chemokines may have roles in the immunopathology of dengue infections and may contribute to fever and bone marrow suppression observed in patients with DV infections. © 2001 Wiley-Liss, Inc.
Source Title: Journal of Medical Virology
URI: http://scholarbank.nus.edu.sg/handle/10635/107671
ISSN: 01466615
DOI: 10.1002/jmv.2037
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