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https://scholarbank.nus.edu.sg/handle/10635/107659
Title: | C4 and 21-hydroxylase gene deletions in nasopharyngeal carcinoma among the Chinese | Authors: | Lim, M. Chan, S.H. |
Keywords: | HLA class III genes Human leucocyte antigen |
Issue Date: | Jan-1996 | Citation: | Lim, M.,Chan, S.H. (1996-01). C4 and 21-hydroxylase gene deletions in nasopharyngeal carcinoma among the Chinese. Annals of the Academy of Medicine Singapore 25 (1) : 42-44. ScholarBank@NUS Repository. | Abstract: | Deletions around the C4 and 21-hydroxylase (21-OH) gene region occur among the Chinese, and C4B together with 21-OHA deletion is the most common. This deletion was found to be strongly associated with human leucocyte antigen (HLA) B58 DRB1*0301, particularly with DRB1*0301. The initial observation of a high frequency of this deletion in nasopharyngeal carcinoma (NPC) was secondary to the B58 DR3 association with NPC. A deletion of 21-OHA alone was observed to be associated with HLA B13 DRB1*1501. | Source Title: | Annals of the Academy of Medicine Singapore | URI: | http://scholarbank.nus.edu.sg/handle/10635/107659 | ISSN: | 03044602 |
Appears in Collections: | Staff Publications |
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