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|Title:||C4 and 21-hydroxylase gene deletions in nasopharyngeal carcinoma among the Chinese|
|Keywords:||HLA class III genes|
Human leucocyte antigen
|Source:||Lim, M.,Chan, S.H. (1996-01). C4 and 21-hydroxylase gene deletions in nasopharyngeal carcinoma among the Chinese. Annals of the Academy of Medicine Singapore 25 (1) : 42-44. ScholarBank@NUS Repository.|
|Abstract:||Deletions around the C4 and 21-hydroxylase (21-OH) gene region occur among the Chinese, and C4B together with 21-OHA deletion is the most common. This deletion was found to be strongly associated with human leucocyte antigen (HLA) B58 DRB1*0301, particularly with DRB1*0301. The initial observation of a high frequency of this deletion in nasopharyngeal carcinoma (NPC) was secondary to the B58 DR3 association with NPC. A deletion of 21-OHA alone was observed to be associated with HLA B13 DRB1*1501.|
|Source Title:||Annals of the Academy of Medicine Singapore|
|Appears in Collections:||Staff Publications|
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