Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/107655
Title: Inhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody
Authors: Loh, M.-T.
Srinivasan, N.
Chan, S.-H. 
Ren, E.-C. 
Issue Date: 1995
Source: Loh, M.-T.,Srinivasan, N.,Chan, S.-H.,Ren, E.-C. (1995). Inhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody. Hybridoma 14 (5) : 429-433. ScholarBank@NUS Repository.
Abstract: Staphylococcal enterotoxins (SE) bind to major histocompatibility complex (MHC) class II molecules and the Vβ region of T cell receptors (TCR) and subsequently induces T cell proliferation. This mitogenicity is the basis of pathological effects seen in food poisoning and toxic shock syndrome. Toxin- specific monoclonal antibodies have previously been shown to be effective in blocking toxin stimulated T cell responses. In this study, a monoclonal antibody, 52BL1, was found to be a potent inhibitor of SEA-, SEB-, SEC1-, SED-, and SEE-induced lymphocyte proliferation assays, which indicates that a single anti-HLA (human leukocyte antigen) class II antibody is effective in blocking the biological effects of these toxins. These results demonstrate the possibility of using anti-HLA class II antibodies in a clinical setting as an antagonist to staphylococcal enterotoxin-mediated pathogenesis.
Source Title: Hybridoma
URI: http://scholarbank.nus.edu.sg/handle/10635/107655
ISSN: 0272457X
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

19
checked on Dec 8, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.