Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/107654
Title: Early inhibition of glycosylation with deoxynojirimycin has no effect on the replication of flavivirus West Nile
Authors: Mah Lee Ng 
Lay Tin Aw
Issue Date: 1994
Source: Mah Lee Ng,Lay Tin Aw (1994). Early inhibition of glycosylation with deoxynojirimycin has no effect on the replication of flavivirus West Nile. Tropical Medicine 36 (1) : 1-13. ScholarBank@NUS Repository.
Abstract: Deoxynojirimycin (dNM) is a specific and reversible inhibitor of the trimming actions of glucosidase I and II in the rough endoplasmic reticulum. The importance of the effects of dNM on the replication of West Nile (sarafend - glycosylated) and West Nile (Wengler - nonglycosylated) viruses were studied. It was found that dNM treatment increase the molecular weights of the E and prM proteins in both virus strains without affecting the yields of the virus. The intracellular transport of the E protein from the rough endoplasmic reticulum to Golgi apparatus was not affected despite the change in molecular weights. It would appear that the prevention of removal of glucose molecules by dNM did not affected the maturation of E protein or the virus.
Source Title: Tropical Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/107654
ISSN: 03855643
Appears in Collections:Staff Publications

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