Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejogrb.2003.09.011
Title: Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery
Authors: Chong, Y.-S. 
Chua, S. 
Shen, L.
Arulkumaran, S. 
Keywords: Misoprostol
Postpartum haemorrhage
Route of administration
Side effects
Uterotonic
Issue Date: 15-Apr-2004
Source: Chong, Y.-S., Chua, S., Shen, L., Arulkumaran, S. (2004-04-15). Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery. European Journal of Obstetrics Gynecology and Reproductive Biology 113 (2) : 191-198. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejogrb.2003.09.011
Abstract: Objective: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes. Study design: Fifty women were given misoprostol 400μg either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters. Results: Uterine activity produced by oral solution misoprostol 400μg was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively). Conclusion: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects. © 2003 Elsevier Ireland Ltd. All rights reserved.
Source Title: European Journal of Obstetrics Gynecology and Reproductive Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/107607
ISSN: 03012115
DOI: 10.1016/j.ejogrb.2003.09.011
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