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|Title:||Role of endothelial cells in IgA nephropathy|
|Keywords:||antivascular endothelial cell antibodies|
HLA class I
unstimulated endothelial cells
|Source:||Yap, H.-K. (1997). Role of endothelial cells in IgA nephropathy. Nephrology 3 (1) : 79-84. ScholarBank@NUS Repository.|
|Abstract:||Various polyspecific autoantibodies have been described in the sera of patients with IgA nephropathy, including anti-IgG, anti-IgA, antigalactosyl, antifibronectin and antimesangial antibodies. We and other authors have demonstrated the presence of antivascular endothelial cell (VEC) antibodies, in up to 32% of patients with IgA nephropathy. These antibodies were directed against molecules on the endothelial cell surface. Some of these antibodies were directed against HLA class I antigens; the majority, however, were reactive against antigens present on unstimulated endothelial cells, as prior stimulation of the cells with interferon-γ or interleukin 1 did not result in an increase in anti-VEC activity of the sera. The clinical significance of these anti-VEC antibodies in IgA nephropathy is unknown. A significant correlation was demonstrated between these antibodies and the presence of heavy proteinuria. A significant association was also shown between the presence of these antibodies and the histopathologic markers of activity such as crescents and focal and segmental necrotizing lesions, as well as immunoglobulin and C3 deposition in the vessel walls.|
|Appears in Collections:||Staff Publications|
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