Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/107539
Title: Molecular genetics of Wilms' tumour
Authors: Tay, J.S.H. 
Keywords: Molecular genetics
Nephroblastoma
Wilms' tumour
Issue Date: 1995
Source: Tay, J.S.H. (1995). Molecular genetics of Wilms' tumour. Journal of Paediatrics and Child Health 31 (5) : 379-383. ScholarBank@NUS Repository.
Abstract: Wilms' tumour, or nephroblastoma, is an embryonal malignancy of the kidney with an incidence of approximately 1 in 10 000 live births. It occurs in both sporadic and familial forms, but only 1% of Wilms' tumour patients have a positive family history. The molecular genetics of Wilms' tumour have been the subject of extensive research and at least three genes (WT1, WT2, WT3) have been implicated. WT1 has been mapped to 11p13, and it has been suggested that loss or inactivation of a tumour-suppressor gene at 11p13 might be a primary event in the development of Wilms' tumour. The WT2 gene maps to 11p15 in the region of the Beckwith-Wiedemann locus. The WT3 locus is likely to be located to chromosome 16q. The understanding of the molecular genetics of Wilms' tumour is reviewed briefly.
Source Title: Journal of Paediatrics and Child Health
URI: http://scholarbank.nus.edu.sg/handle/10635/107539
ISSN: 10344810
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

44
checked on Mar 9, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.