A novel transthyretin mutation V32A in a Chinese man with late-onset amyloid polyneuropathy

Abstract

We report a Chinese patient with amyloidotic polyneuropathy associated with a novel transthyretin mutation (V32A). He presented with slowly progressive sensorimotor polyneuropathy accompanied by autonomic dysfunction and cardiomyopathy by echocardiography. This mutation is likely to be associated with late onset and low-penetrance phenotype. © 2005 Wiley Periodicals, Inc.