Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/107454
DC Field | Value | |
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dc.title | IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production | |
dc.contributor.author | Verri Jr., W.A. | |
dc.contributor.author | Cunha, T.M. | |
dc.contributor.author | Ferreira, S.H. | |
dc.contributor.author | Wei, X. | |
dc.contributor.author | Leung, B.P. | |
dc.contributor.author | Fraser, A. | |
dc.contributor.author | McInnes, I.B. | |
dc.contributor.author | Liew, F.Y. | |
dc.contributor.author | Cunha, F.Q. | |
dc.date.accessioned | 2014-11-06T08:23:47Z | |
dc.date.available | 2014-11-06T08:23:47Z | |
dc.date.issued | 2007-12 | |
dc.identifier.citation | Verri Jr., W.A., Cunha, T.M., Ferreira, S.H., Wei, X., Leung, B.P., Fraser, A., McInnes, I.B., Liew, F.Y., Cunha, F.Q. (2007-12). IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production. European Journal of Immunology 37 (12) : 3373-3380. ScholarBank@NUS Repository. | |
dc.identifier.issn | 00142980 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/107454 | |
dc.description.abstract | We have investigated the mechanisms underlying IL-15-induced neutrophil migration into inflamed tissues. IL-15 induced neutrophil migration to the peritoneal cavity in mice in a time- and dose-dependent manner. The cell migration was not induced in IL-18 -/-, MIP-1α (CCL3) -/-, TNFR1 -/- or 5-LOX -/- mice but was normal in IFN-γ -/- mice. IL-15-induced neutrophil migration was inhibited by anti-MIP-2 (CXCL2) antibody or MK886 (leukotriene synthesis inhibitor). IL-18-induced neutrophil migration was also dependent on TNFR1, MIP-1α, MIP-2 and leukotriene. Consistent with this observation, IL-15 induced IL-18 production, and IL-15 or IL-18 injection induced the production of MIP-2, MIP-1α, TNF-α and LTB 4. In an antigen-specific inflammation model, ovalbumin (OVA)-induced neutrophil migration was completely inhibited by soluble IL-15Rα (sIL-15Rα) or anti-MIP-2 antibody. Furthermore, cell migration was absent in IL-18 -/-, MIP-1α -/-, TNFR1 -/-, or 5-LOX -/- mice. OVA challenge induced the release of MIP-2, MIP-1α, TNF-α and LTB 4 in the peritoneal cavity in an IL-15- and IL-18-dependent manner. We also found that neutrophils from the peripheral blood and synovial fluid of patients with rheumatoid arthritis produced substantial amounts of IL-18 and LTB 4 following activation by IL-15. Together, these results demonstrate that IL-15 plays an important role in antigen-induced neutrophil migration during inflammation, triggering a sequential OVA, IL-15, IL-18, MIP-2, MIP-1α, TNF-α, LTB 4 and neutrophil migration signaling cascade. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/eji.200737488 | |
dc.source | Scopus | |
dc.subject | Autoimmunity | |
dc.subject | Chemokines | |
dc.subject | IL-15 | |
dc.subject | Neutrophils | |
dc.subject | Rheumatoid arthritis | |
dc.type | Article | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.sourcetitle | European Journal of Immunology | |
dc.description.volume | 37 | |
dc.description.issue | 12 | |
dc.description.page | 3373-3380 | |
dc.description.coden | EJIMA | |
dc.identifier.isiut | 000251956800014 | |
Appears in Collections: | Staff Publications |
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