Please use this identifier to cite or link to this item:
|Title:||IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production|
|Authors:||Verri Jr., W.A.|
|Citation:||Verri Jr., W.A., Cunha, T.M., Ferreira, S.H., Wei, X., Leung, B.P., Fraser, A., McInnes, I.B., Liew, F.Y., Cunha, F.Q. (2007-12). IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production. European Journal of Immunology 37 (12) : 3373-3380. ScholarBank@NUS Repository.|
|Abstract:||We have investigated the mechanisms underlying IL-15-induced neutrophil migration into inflamed tissues. IL-15 induced neutrophil migration to the peritoneal cavity in mice in a time- and dose-dependent manner. The cell migration was not induced in IL-18 -/-, MIP-1α (CCL3) -/-, TNFR1 -/- or 5-LOX -/- mice but was normal in IFN-γ -/- mice. IL-15-induced neutrophil migration was inhibited by anti-MIP-2 (CXCL2) antibody or MK886 (leukotriene synthesis inhibitor). IL-18-induced neutrophil migration was also dependent on TNFR1, MIP-1α, MIP-2 and leukotriene. Consistent with this observation, IL-15 induced IL-18 production, and IL-15 or IL-18 injection induced the production of MIP-2, MIP-1α, TNF-α and LTB 4. In an antigen-specific inflammation model, ovalbumin (OVA)-induced neutrophil migration was completely inhibited by soluble IL-15Rα (sIL-15Rα) or anti-MIP-2 antibody. Furthermore, cell migration was absent in IL-18 -/-, MIP-1α -/-, TNFR1 -/-, or 5-LOX -/- mice. OVA challenge induced the release of MIP-2, MIP-1α, TNF-α and LTB 4 in the peritoneal cavity in an IL-15- and IL-18-dependent manner. We also found that neutrophils from the peripheral blood and synovial fluid of patients with rheumatoid arthritis produced substantial amounts of IL-18 and LTB 4 following activation by IL-15. Together, these results demonstrate that IL-15 plays an important role in antigen-induced neutrophil migration during inflammation, triggering a sequential OVA, IL-15, IL-18, MIP-2, MIP-1α, TNF-α, LTB 4 and neutrophil migration signaling cascade. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||European Journal of Immunology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 27, 2018
WEB OF SCIENCETM
checked on Apr 16, 2018
checked on May 18, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.