Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/106981
DC Field | Value | |
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dc.title | Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice | |
dc.contributor.author | Chew, J.L. | |
dc.contributor.author | Wolfowicz, C.B. | |
dc.contributor.author | Mao, H.-Q. | |
dc.contributor.author | Leong, K.W. | |
dc.contributor.author | Chua, K.Y. | |
dc.date.accessioned | 2014-10-29T08:37:48Z | |
dc.date.available | 2014-10-29T08:37:48Z | |
dc.date.issued | 2003-06-20 | |
dc.identifier.citation | Chew, J.L., Wolfowicz, C.B., Mao, H.-Q., Leong, K.W., Chua, K.Y. (2003-06-20). Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine 21 (21-22) : 2720-2729. ScholarBank@NUS Repository. | |
dc.identifier.issn | 0264410X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/106981 | |
dc.description.abstract | Our previous studies indicated that intramuscular (i.m.) immunisation with full length Der p 1 cDNA induced significant humoral response to the left domain (approximately corresponding to amino acids 1-116) but not to the right domain (approximately corresponding to amino acids 117-222) of Der p 1 allergen. This study explored the use of chitosan-DNA nanoparticles for oral immunisation to induce immune responses specific to both the left and right domains of Der p 1. DNA constructs pDer p 1 (1-222) and pDer p 1 (114-222) were complexed with chitosan and delivered orally followed by an i.m. injection of pDer p 1 (1-222) 13 weeks later. Such approach has successfully primed Th1-skewed immune responses against both domains of Der p 1. This strategy could be further optimised for more efficacious gene vaccination for full length Der p 1. © 2003 Elsevier Science Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0264-410X(03)00228-7 | |
dc.source | Scopus | |
dc.subject | Chitosan nanoparticles | |
dc.subject | Der p 1 | |
dc.subject | Oral | |
dc.type | Article | |
dc.contributor.department | MATERIALS SCIENCE | |
dc.description.sourcetitle | Vaccine | |
dc.description.volume | 21 | |
dc.description.issue | 21-22 | |
dc.description.page | 2720-2729 | |
dc.description.coden | VACCD | |
dc.identifier.isiut | 000183709300006 | |
Appears in Collections: | Staff Publications |
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