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Title: The reality of in-line tablet coating
Authors: Cahyadi, C.
Chan, L.W. 
Heng, P.W.S. 
Keywords: Coating defects
Internal stress
Stress relaxation
Tablet coating
Tablet compaction
Viscoelastic strain recovery
Issue Date: Feb-2013
Citation: Cahyadi, C., Chan, L.W., Heng, P.W.S. (2013-02). The reality of in-line tablet coating. Pharmaceutical Development and Technology 18 (1) : 2-16. ScholarBank@NUS Repository.
Abstract: The possibility of continuous processing in pharmaceutical tablet manufacturing is hampered by the viscoelastic recovery of tablets post-compaction. Compacted tablets are typically aged before coating to allow complete viscoelastic recovery so as to avoid subsequent coating defects. There has been little attempt to overcome tablet recovery in order to enable continuous processing and improve manufacturing efficiency. However, with the introduction of improved or newly developed types of tablet-coating equipment, there is renewed interest in the coating of tablets in-line. In-line tablet coating is defined as the coating of tablets immediately after compaction. It is a one-step highly integrated system that circumvents the delay in processing time typically given to allow viscoelastic recovery of tablets. This review aims to summarize the requirements of an in-line tablet-coating system. The possibility of carrying out in-line tablet coating in the near future will also be discussed. © 2013 Informa Healthcare USA, Inc.
Source Title: Pharmaceutical Development and Technology
ISSN: 10837450
DOI: 10.3109/10837450.2011.586039
Appears in Collections:Staff Publications

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