Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00018-009-0016-4
Title: The effect of photodynamic therapy on tumor angiogenesis
Authors: Bhuvaneswari, R.
Gan, Y.Y.
Soo, K.C.
Olivo, M. 
Keywords: Angiogenesis
Angiogenic inhibitors
Cancer
Cyclooxygenase-2 (COX-2)
Photodynamic therapy (PDT)
Vascular endothelial growth factor (VEGF)
Issue Date: Jul-2009
Citation: Bhuvaneswari, R., Gan, Y.Y., Soo, K.C., Olivo, M. (2009-07). The effect of photodynamic therapy on tumor angiogenesis. Cellular and Molecular Life Sciences 66 (14) : 2275-2283. ScholarBank@NUS Repository. https://doi.org/10.1007/s00018-009-0016-4
Abstract: Photodynamic therapy (PDT), the activation of a photosensitive drug in tumor tissue with light of specific wavelength, has been used effectively to treat certain solid tumors. Though therapeutic responses are encouraging, PDT-mediated oxidative stress can act as an angiogenic switch that ultimately leads to neovascularization and tumor recurrence. This article explores the effect of PDT on angiogenesis in different tumor models. Overexpression of proangiogenic vascular endothelial growth factor, cyclooxygenase-2 and matrix metalloproteases has often been reported post-illumination. Recent clinical studies have demonstrated that inhibiting angiogenesis after chemotherapy and radiotherapy is an attractive and valuable approach to cancer treatment. In this review, we report the effective therapeutic strategy of combining angiogenesis inhibitors with PDT to control and treat tumors. © 2009 Birkhäuser Verlag, Basel/Switzerland.
Source Title: Cellular and Molecular Life Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/106713
ISSN: 1420682X
DOI: 10.1007/s00018-009-0016-4
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