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Title: Design of β-turn based therapeutic agents
Authors: Suat Kee, K.
Jois, S.D.S. 
Issue Date: 2003
Citation: Suat Kee, K.,Jois, S.D.S. (2003). Design of β-turn based therapeutic agents. Current Pharmaceutical Design 9 (15) : 1209-1224. ScholarBank@NUS Repository.
Abstract: Peptides and proteins are essential to many biological processes. The interaction between tile peptide ligands and their receptor targets commonly involves β-turn structures. Yet poor bioavailability and unfavorable pharmacokinetics significantly compromise the use of peptides as drugs. Thus, there has been a great deal of interest in the design of peptidomimetics (modified peptides) as therapeutic agents by mimicking β-turn structures. This review highlights the importance of β-turn in the design of various peptidomimetics for many diseases. This review also outlines several β-turn mimicking strategies and its application in the design of potent peptide analogues. β-turn mimetics often tend to be more rigid in positioning the critically important amino acid residues and thus optimize the surface conformation for productive interaction with the receptors.
Source Title: Current Pharmaceutical Design
ISSN: 13816128
DOI: 10.2174/1381612033454900
Appears in Collections:Staff Publications

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