Please use this identifier to cite or link to this item:
|Title:||Design of β-turn based therapeutic agents|
|Authors:||Suat Kee, K.|
|Citation:||Suat Kee, K.,Jois, S.D.S. (2003). Design of β-turn based therapeutic agents. Current Pharmaceutical Design 9 (15) : 1209-1224. ScholarBank@NUS Repository. https://doi.org/10.2174/1381612033454900|
|Abstract:||Peptides and proteins are essential to many biological processes. The interaction between tile peptide ligands and their receptor targets commonly involves β-turn structures. Yet poor bioavailability and unfavorable pharmacokinetics significantly compromise the use of peptides as drugs. Thus, there has been a great deal of interest in the design of peptidomimetics (modified peptides) as therapeutic agents by mimicking β-turn structures. This review highlights the importance of β-turn in the design of various peptidomimetics for many diseases. This review also outlines several β-turn mimicking strategies and its application in the design of potent peptide analogues. β-turn mimetics often tend to be more rigid in positioning the critically important amino acid residues and thus optimize the surface conformation for productive interaction with the receptors.|
|Source Title:||Current Pharmaceutical Design|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 16, 2018
checked on Sep 28, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.