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|Title:||Design of β-turn based therapeutic agents|
|Authors:||Suat Kee, K.|
|Source:||Suat Kee, K.,Jois, S.D.S. (2003). Design of β-turn based therapeutic agents. Current Pharmaceutical Design 9 (15) : 1209-1224. ScholarBank@NUS Repository. https://doi.org/10.2174/1381612033454900|
|Abstract:||Peptides and proteins are essential to many biological processes. The interaction between tile peptide ligands and their receptor targets commonly involves β-turn structures. Yet poor bioavailability and unfavorable pharmacokinetics significantly compromise the use of peptides as drugs. Thus, there has been a great deal of interest in the design of peptidomimetics (modified peptides) as therapeutic agents by mimicking β-turn structures. This review highlights the importance of β-turn in the design of various peptidomimetics for many diseases. This review also outlines several β-turn mimicking strategies and its application in the design of potent peptide analogues. β-turn mimetics often tend to be more rigid in positioning the critically important amino acid residues and thus optimize the surface conformation for productive interaction with the receptors.|
|Source Title:||Current Pharmaceutical Design|
|Appears in Collections:||Staff Publications|
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