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https://doi.org/10.1615/IntJMedMushr.v8.i4.30
Title: | Water-soluble polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) alleviate the dose-limiting toxicities of irinotecan (CPT-11) | Authors: | Hu, Z. Chen, X. Yang, X. Gao, Y. Zhou, S. |
Keywords: | Diarrhea Ganoderma lucidum Irinotecan (CPT-11) Myelosuppression Polysaccharide |
Issue Date: | 2006 | Citation: | Hu, Z.,Chen, X.,Yang, X.,Gao, Y.,Zhou, S. (2006). Water-soluble polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) alleviate the dose-limiting toxicities of irinotecan (CPT-11). International Journal of Medicinal Mushrooms 8 (4) : 321-327. ScholarBank@NUS Repository. https://doi.org/10.1615/IntJMedMushr.v8.i4.30 | Abstract: | Ganoderma lucidum extracts attenuated cisplatin-induced nausea and vomiting in rats. The clinical use of irinotecan (CPT-11) is hindered by dose-limiting diarrhea and myelosuppression. This study aimed to investigate whether a combination of G. lucidum polysaccharides (25 mg/kg by gavage) modulated the toxicities of CPT-11 in rats. The rat toxicity model was constructed by treatment of CPT-11 at 60 mg/kg/day by intravenous injection. Incidence of acute and delayed-onset diarrhea, blood cell counts, and body weight were monitored throughout the study. Administration of CPT-11 and a control vehicle (sterile water) for four days to rats induced a significant decrease in neutrophils and lymphocytes counts, body weight loss, and severe acute and delayed-onset diarrhea. These toxicities were suppressed when CPT-11 was combined with G. lucidum polysaccharides. Further study is needed to explore the mechanisms for the protective effect of G. lucidum polysaccharides against CPT-11 toxicity. © 2006 by Begell House, Inc. | Source Title: | International Journal of Medicinal Mushrooms | URI: | http://scholarbank.nus.edu.sg/handle/10635/106509 | ISSN: | 15219437 | DOI: | 10.1615/IntJMedMushr.v8.i4.30 |
Appears in Collections: | Staff Publications |
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