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|Title:||Transport of angiotensin peptides across the Caco-2 monolayer|
Mechanisms of transport
|Citation:||Chua, H.-L., Jois, S., Sim, M.-K., Go, M.-L. (2004-08). Transport of angiotensin peptides across the Caco-2 monolayer. Peptides 25 (8) : 1327-1338. ScholarBank@NUS Repository. https://doi.org/10.1016/j.peptides.2004.06.009|
|Abstract:||The bidirectional transport of the angiotensin peptides - des-Asp-angiotensin I (DAAI), angiotensins III and IV - were studied using human intestinal Caco-2 monolayers. The peptides had low permeability rates but were relatively stable to enzymatic hydrolysis. DAAI was transported by diffusion while angiotensins III and IV were transported by an energy requiring, carrier-mediated process. The physicochemical properties and solution conformations of the peptides were investigated in an attempt to establish structure-transport correlations. Among the three peptides, DAAI was the most hydrophobic, had the highest hydrogen bonding potential and was the only peptide to have a random solution conformation, as determined from circular dichroism, two-dimensional 1H NMR and molecular modelling. On the other hand, the more hydrophilic angiotensin IV had less hydrogen bonding potential and a solution conformation characterized by a β turn. These factors may influence the transport characteristics of DAAI and angiotensin IV. © 2004 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Staff Publications|
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