Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-5173(02)00213-2
Title: The influence of operational variables on mean size and size distribution of spheroids produced by rotary spheronization using teardrop studs
Authors: Liew, C.V. 
Gu, L.
Heng, P.W.S. 
Keywords: Orthogonal design
Rotary processor
Spheronization
Issue Date: 21-Aug-2002
Citation: Liew, C.V., Gu, L., Heng, P.W.S. (2002-08-21). The influence of operational variables on mean size and size distribution of spheroids produced by rotary spheronization using teardrop studs. International Journal of Pharmaceutics 242 (1-2) : 345-348. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-5173(02)00213-2
Abstract: The rotary processor can be used for single step spheroid production directly from powder with multiple formulation and process variables involved. In this study, a frictional base plate with teardrop studs was used. Four selected independent variables, base plate rotational speed during liquid addition (A), spray rate of water (B), total amount of water added (C) and base plate rotational speed during the tumbling stage (D), were put into an orthogonal design with three levels for each variable. Mean spheroid size and size distribution were used as the response variables to evaluate the effect of these independent variables. The variables C and D were identified as more important among the four variables and should be at optimal levels for producing good quality spheroids. © 2002 Elsevier Science B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/106441
ISSN: 03785173
DOI: 10.1016/S0378-5173(02)00213-2
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