Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106439
Title: The influence of liquid spray rate and atomizing pressure on the size of spray droplets and spheroids
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Liew, C.V. 
Keywords: Atomizing pressure
Liquid spray rate
Spheroid
Spheroid size
Spray droplet size
Issue Date: 16-May-1995
Citation: Wan, L.S.C.,Heng, P.W.S.,Liew, C.V. (1995-05-16). The influence of liquid spray rate and atomizing pressure on the size of spray droplets and spheroids. International Journal of Pharmaceutics 118 (2) : 213-219. ScholarBank@NUS Repository.
Abstract: The effects of liquid spray rate and atomizing pressure on the size of spray droplets and spheroids were investigated in this study. The range of droplet sizes tended to narrow and relatively smaller droplets were formed at higher atomizing pressures. When liquid spray rate was increased, the droplets were larger and had a wider size range. Although alterations in liquid spray rate could affect spray droplet size, greater changes in droplet size were achieved by varying atomizing pressure. In these investigations, changes in spray droplet size and atomizing pressure did not appear to greatly affect mean spheroid size. However, the presence of an atomizing pressure was necessary for the even distribution of the moistening liquid to reduce localized overwetting during spheronization by rotary processing. The amount of oversized particles may thus be decreased and a more uniformly sized yield may be achieved with the use of relatively higher atomizing pressures. With a fixed volume of moistening liquid sufficient for spheronization, larger spheroids were produced with increasing liquid spray rates. The increased wetting per unit time resulted in the formation of larger nuclei and enhanced the growth rate of spheroids. © 1995.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/106439
ISSN: 03785173
Appears in Collections:Staff Publications

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