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Title: The influence of antitack additives on drug release from film-coated granules
Authors: Wan, L.S.C. 
Lai, W.F.
Keywords: Additive-polymer interaction
Antitack additive
Aqueous film coating
Diphenhydramine HCl
Drug release
Issue Date: 21-Jun-1993
Citation: Wan, L.S.C.,Lai, W.F. (1993-06-21). The influence of antitack additives on drug release from film-coated granules. International Journal of Pharmaceutics 94 (1-3) : 39-47. ScholarBank@NUS Repository.
Abstract: In this report, the effect of various antitack additives on the overall drug release properties of methylcellulose (MC) film-coated granules is described, with emphasis on the drug release-enhancing ability of magnesium stearate when it is incorporated as an antitack agent in aqueous MC coating formulations. All the other additives were also found to cause a rise in the release rate of the drug from the coated granules, although it was much less compared with magnesium stearate. The reasons for the effect of the additives on the release properties of the coated product were explored and discussed in terms of the swelling behaviour of the coated granules in water and the possible additive-polymer interactions. The results of the study are important in the film coating of multiparticulate dosage forms with aqueous-based polymeric formulations in which a generally high level of antitack additives is used. © 1993.
Source Title: International Journal of Pharmaceutics
ISSN: 03785173
Appears in Collections:Staff Publications

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