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|Title:||The antimalarial agent halofantrine perturbs phosphatidylcholine and phosphatidylethanolamine bilayers: A differential scanning calorimetric study|
|Authors:||Lim, L.-Y. |
Differential scanning calorimetry
|Citation:||Lim, L.-Y.,Go, M.-L. (1999-06). The antimalarial agent halofantrine perturbs phosphatidylcholine and phosphatidylethanolamine bilayers: A differential scanning calorimetric study. Chemical and Pharmaceutical Bulletin 47 (6) : 732-737. ScholarBank@NUS Repository.|
|Abstract:||The interaction of halofantrine with phosphatidylcholine and phosphatidylethanolamine bilayers has been investigated by differential scanning calorimetry. Halofantrine caused a broadening of the gel to liquid crystalline phase transition endotherm of the phosphatidylcholines. A decrease in the transition temperature T(m) and enthalpy (ΔH) of transition was also observed. This varied with the chain length of the phospholipid and was more pronounced with short chain members. Halofantrine-induced changes to the thermotropic characteristics of dipalmitoylphosphatidylcholine (DPPC)/cholesterol bilayers suggested that the penetration of halofantrine into the bilayer was diminished in the presence of cholesterol. A more complex calorimetric profile was observed in the interaction of halofantrine with phosphatidylethanolamines and the results suggested that halofantrine did not disrupt the cooperativity of the phosphatidylethanolamine bilayers to the same extent as that observed with the phosphatidylcholines. Halofantrine caused significant perturbation of phospholipids and this property might have an important bearing on its pharmacodynamic effects.|
|Source Title:||Chemical and Pharmaceutical Bulletin|
|Appears in Collections:||Staff Publications|
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