Please use this identifier to cite or link to this item: https://doi.org/10.1002/jps.10160
Title: Terpenes in propylene glycol as skin-penetration enhancers: Permeation and partition of haloperidol, fourier transform infrared spectroscopy, and differential scanning calorimetry
Authors: Vaddi, H.K.
Ho, P.C. 
Chan, S.Y. 
Keywords: DSC
FT-IR
Haloperidol
Human skin
Permeation
SC binding
Terpenes
Issue Date: 2002
Source: Vaddi, H.K., Ho, P.C., Chan, S.Y. (2002). Terpenes in propylene glycol as skin-penetration enhancers: Permeation and partition of haloperidol, fourier transform infrared spectroscopy, and differential scanning calorimetry. Journal of Pharmaceutical Sciences 91 (7) : 1639-1651. ScholarBank@NUS Repository. https://doi.org/10.1002/jps.10160
Abstract: The respective alcoholic terpenes carvacrol, linalool, and α-terpineol were used at 5% w/v in propylene glycol (PG) to increase the in vitro permeation of haloperidol (HP) through human skin. The possible enhancement mechanism was then elucidated with HP-stratum corneum (SC) binding studies, Fourier transform infrared spectroscopy, and differential scanning calorimetry. The greatest increase in the permeation of HP was achieved with linalool followed by carvacrol and terpineol. HP permeation with linalool was predicted to reach a therapeutic plasma concentration and therapeutic daily-permeated amounts. Carvacrol increased lag time, which was attributed to slow redistribution of the enhancer within SC. Carvacrol increased the partition of the drug to the pulverized SC. Pure PG extracted lipids from SC but less than that achieved by the terpenes in PG. Terpenes extracted lipids to a similar extent. An increase in bilayer cohesion in the remaining lipids present in the SC could be attributed to the alignment of terpenes within the lipid bilayer. The higher permeation with linalool was attributed to its molecular orientation within the lipid bilayer. Terpenes showed different rates of SC dehydration but did not change the percentages of secondary structures of keratin. © 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association.
Source Title: Journal of Pharmaceutical Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/106418
ISSN: 00223549
DOI: 10.1002/jps.10160
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

114
checked on Feb 15, 2018

WEB OF SCIENCETM
Citations

93
checked on Jan 30, 2018

Page view(s)

33
checked on Feb 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.