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|Title:||Synthesis of new heterocyclic system: 1(5)H-1,5-diazacycl[3.3.2]azine-2,4-dione|
|Authors:||Dolzhenko, A.V. |
|Citation:||Dolzhenko, A.V.,Dolzhenko, A.V.,Chui, W.-K. (2007-09-01). Synthesis of new heterocyclic system: 1(5)H-1,5-diazacycl[3.3.2]azine-2,4-dione. Heterocycles 71 (9) : 2049-2054. ScholarBank@NUS Repository.|
|Abstract:||A synthesis of hitherto unknown heterocyclic system 1(5)H-1,5-diazacycl[3.3.2]azine-2,4-dione (5) is presented. The cyclocondensation of 2,6-diaminopyridine (1) with maleic anhydride yielded (5-amino-2-oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)acetic acid (2), which was converted to methyl (5-amino-2-oxo-2,3-dihydroimidazo[1,2-a[pyridin-3-yl) acetate hydrochloride (3). The ester (3) upon treatment with sodium carbonate solution underwent intramolecular cyclization to 2a,3-dihydro-1(5)H-1,5-diazacycl[3.3.2]azine-2,4-dione (4), which was oxidized in alkaline condition to provide 5. © 2007 The Japan Institute of Heterocyclic Chemistry.|
|Appears in Collections:||Staff Publications|
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