Please use this identifier to cite or link to this item:
|Title:||Synthesis of ethyl 6-aryl-4-oxo-4,6-dihydro-1(12)(13)H-pyrimido-[2′, 1′:4,5][1,3,5]triazino[1,2-a]benzimidazole-3-carboxylates|
|Authors:||Dolzhenko, A.V. |
|Citation:||Dolzhenko, A.V., Chui, W.-K., Dolzhenko, A.V. (2006-11). Synthesis of ethyl 6-aryl-4-oxo-4,6-dihydro-1(12)(13)H-pyrimido-[2′, 1′:4,5][1,3,5]triazino[1,2-a]benzimidazole-3-carboxylates. Journal of Heterocyclic Chemistry 43 (6) : 1513-1521. ScholarBank@NUS Repository. https://doi.org/10.1002/jhet.5570430614|
|Abstract:||The synthesis of ethyl 6-aryl-4-oxo-4,6-dihydro-1(12)(13)H- pyrimido[2′,1′:4,5][1,3,5]triazino[1,2-a]-benzimidazole-3- carboxylates (4a-p) was described via pyrimidine ring annulation to 4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole-2-amines (2a-p) which were obtained from 2-guanidinobenzimidazole (1). Tautomerism in the prepared compounds was investigated using nmr spectroscopy. Compounds 2a-p were found to be present in dimethyl sulfoxide solution predominantly as 3,4-dihydro tautomeric form. Compounds 4a-p existed in dynamic equilibrium of 1-, 12- and 13H- forms. It was found that methylation of 4a-d led to 13-methyl substituted derivatives 9a-d exclusively.|
|Source Title:||Journal of Heterocyclic Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 12, 2018
WEB OF SCIENCETM
checked on Sep 26, 2018
checked on Sep 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.