Please use this identifier to cite or link to this item: https://doi.org/10.1080/02652030500479690
Title: Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product
Authors: Zou, P.
Hou, P.
Low, M.-Y.
Koh, H.-L. 
Keywords: Adulteration
Erectile dysfunction
Herbal product
Hydroxyhomosildenafil
Tadalafil analogue
Issue Date: May-2006
Citation: Zou, P., Hou, P., Low, M.-Y., Koh, H.-L. (2006-05). Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product. Food Additives and Contaminants 23 (5) : 446-451. ScholarBank@NUS Repository. https://doi.org/10.1080/02652030500479690
Abstract: A tadalafil analogue and hydroxyhomosildenafil were isolated from a herbal product marketed for erectile dysfunction. The structure of the tadalafil analogue was elucidated using LC-UV, high resolution MS, ESI-MS/MS, IR, and NMR. The compound was determined to be (6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione. This compound should be included as a target compound when screening for adulterants in herbal products. This is the first published paper on a tadalafil analogue and hydroxyhomosildenafil found as adulterants of a herbal product. © 2006 Taylor & Francis.
Source Title: Food Additives and Contaminants
URI: http://scholarbank.nus.edu.sg/handle/10635/106366
ISSN: 0265203X
DOI: 10.1080/02652030500479690
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