Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jpba.2008.08.019
Title: Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement
Authors: Ge, X.
Low, M.-Y.
Zou, P.
Lin, L.
Yin, S.O.S.
Bloodworth, B.C.
Koh, H.-L. 
Keywords: Adulterant
Health supplement
Liquid chromatography (LC)
Mass spectrometry (MS)
Nuclear magnetic resonance (NMR)
PDE-5 inhibitor
Issue Date: 1-Dec-2008
Citation: Ge, X., Low, M.-Y., Zou, P., Lin, L., Yin, S.O.S., Bloodworth, B.C., Koh, H.-L. (2008-12-01). Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement. Journal of Pharmaceutical and Biomedical Analysis 48 (4) : 1070-1075. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpba.2008.08.019
Abstract: A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1H-imidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor. © 2008 Elsevier B.V. All rights reserved.
Source Title: Journal of Pharmaceutical and Biomedical Analysis
URI: http://scholarbank.nus.edu.sg/handle/10635/106365
ISSN: 07317085
DOI: 10.1016/j.jpba.2008.08.019
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Oct 18, 2018

WEB OF SCIENCETM
Citations

17
checked on Oct 2, 2018

Page view(s)

36
checked on Oct 5, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.