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https://doi.org/10.1016/j.jpba.2008.08.019
Title: | Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement | Authors: | Ge, X. Low, M.-Y. Zou, P. Lin, L. Yin, S.O.S. Bloodworth, B.C. Koh, H.-L. |
Keywords: | Adulterant Health supplement Liquid chromatography (LC) Mass spectrometry (MS) Nuclear magnetic resonance (NMR) PDE-5 inhibitor |
Issue Date: | 1-Dec-2008 | Citation: | Ge, X., Low, M.-Y., Zou, P., Lin, L., Yin, S.O.S., Bloodworth, B.C., Koh, H.-L. (2008-12-01). Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement. Journal of Pharmaceutical and Biomedical Analysis 48 (4) : 1070-1075. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpba.2008.08.019 | Abstract: | A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1H-imidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor. © 2008 Elsevier B.V. All rights reserved. | Source Title: | Journal of Pharmaceutical and Biomedical Analysis | URI: | http://scholarbank.nus.edu.sg/handle/10635/106365 | ISSN: | 07317085 | DOI: | 10.1016/j.jpba.2008.08.019 |
Appears in Collections: | Staff Publications |
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