Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201001122
Title: Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities
Authors: Wang, Z.
Ho, P.C. 
Keywords: cancer
drug delivery
nanocapsules
self-assembly
Issue Date: 22-Nov-2010
Citation: Wang, Z., Ho, P.C. (2010-11-22). Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities. Small 6 (22) : 2576-2583. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201001122
Abstract: A biocompatible and degradable self-assembled core-shell nanocapsule is synthesized with targeting ability to tumor vasculature endothelial cells, followed by sequential delivery of anti-angiogenesis and anticancer drugs. The uptake of this nanocapsule by human umbilical vein endothelial cells (HUVEC) is efficient, and the two loaded drugs maintain their respective therapeutic potency. The time-dependent sequential release of these two drugs resulted in selective ablation of endothelial and cancer cells. This promising core-shell nanocapsule may open another avenue to fight cancer. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Small
URI: http://scholarbank.nus.edu.sg/handle/10635/106325
ISSN: 16136810
DOI: 10.1002/smll.201001122
Appears in Collections:Staff Publications

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