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|Title:||Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities|
|Source:||Wang, Z., Ho, P.C. (2010-11-22). Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities. Small 6 (22) : 2576-2583. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201001122|
|Abstract:||A biocompatible and degradable self-assembled core-shell nanocapsule is synthesized with targeting ability to tumor vasculature endothelial cells, followed by sequential delivery of anti-angiogenesis and anticancer drugs. The uptake of this nanocapsule by human umbilical vein endothelial cells (HUVEC) is efficient, and the two loaded drugs maintain their respective therapeutic potency. The time-dependent sequential release of these two drugs resulted in selective ablation of endothelial and cancer cells. This promising core-shell nanocapsule may open another avenue to fight cancer. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Appears in Collections:||Staff Publications|
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