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|Title:||S-Allylcysteine reduces breast tumor cell adhesion and invasion|
|Authors:||Gapter, L.A. |
|Citation:||Gapter, L.A., Yuin, O.Z., Ng, K.-y. (2008-03-07). S-Allylcysteine reduces breast tumor cell adhesion and invasion. Biochemical and Biophysical Research Communications 367 (2) : 446-451. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2007.12.175|
|Abstract:||Previous studies show that aqueous garlic extract and its derivatives (e.g. S-allylcysteine [SAC]) prevent carcinogen-induced breast tumorigenesis. However, investigations testing the effect of SAC on later stages of breast tumorigenesis and/or metastasis have produced mixed results. Here we show that SAC significantly reduced anchorage-dependent and -independent growth of MDA-MB-231 breast tumor cells in a dose- and time-dependent fashion, and sub-lethal SAC-treatment altered mammary tumor cell adhesion and invasion through components of the extracellular matrix. We provide evidence to suggest increased expression of E-cadherin and reduced MMP-2 expression and activity are partially responsible for inhibition of mammary tumor cell invasion by SAC. Because E-cadherin and MMP-2 are important in cancer metastasis, these results suggest a link between SAC induction of E-cadherin and reduction of MMP2 activity with the inhibition of cell motility and invasion; thus providing evidence that events leading to breast cancer metastasis are repressed by sub-lethal SAC-treatment. © 2007 Elsevier Inc. All rights reserved.|
|Source Title:||Biochemical and Biophysical Research Communications|
|Appears in Collections:||Staff Publications|
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