S-Allylcysteine reduces breast tumor cell adhesion and invasion
Gapter, L.A. Yuin, O.Z. Ng, K.-y.
Yuin, O.Z.
Citations
Altmetric:
Alternative Title
Abstract
Previous studies show that aqueous garlic extract and its derivatives (e.g. S-allylcysteine [SAC]) prevent carcinogen-induced breast tumorigenesis. However, investigations testing the effect of SAC on later stages of breast tumorigenesis and/or metastasis have produced mixed results. Here we show that SAC significantly reduced anchorage-dependent and -independent growth of MDA-MB-231 breast tumor cells in a dose- and time-dependent fashion, and sub-lethal SAC-treatment altered mammary tumor cell adhesion and invasion through components of the extracellular matrix. We provide evidence to suggest increased expression of E-cadherin and reduced MMP-2 expression and activity are partially responsible for inhibition of mammary tumor cell invasion by SAC. Because E-cadherin and MMP-2 are important in cancer metastasis, these results suggest a link between SAC induction of E-cadherin and reduction of MMP2 activity with the inhibition of cell motility and invasion; thus providing evidence that events leading to breast cancer metastasis are repressed by sub-lethal SAC-treatment. © 2007 Elsevier Inc. All rights reserved.
Keywords
Breast cancer, E-cadherin, Garlic, Matrix metalloprotease, MDA-MB-231, Metastasis, MMP, S-Allylcysteine, SAC, Tumor growth
Source Title
Biochemical and Biophysical Research Communications
Publisher
Series/Report No.
Collections
Rights
Date
2008-03-07
DOI
10.1016/j.bbrc.2007.12.175
Type
Article