Please use this identifier to cite or link to this item:
|Title:||Roller compaction of crude plant material: Influence of process variables, polyvinylpyrrolidone, and co-milling|
|Authors:||Heng, P.W.S. |
|Citation:||Heng, P.W.S., Chan, L.W., Liew, C.V., Chee, S.N., Soh, J.L.P., Ooi, S.M. (2004). Roller compaction of crude plant material: Influence of process variables, polyvinylpyrrolidone, and co-milling. Pharmaceutical Development and Technology 9 (2) : 135-144. ScholarBank@NUS Repository. https://doi.org/10.1081/PDT-120027425|
|Abstract:||Roller compaction of a milled botanical (Baphicacanthus cusia) with and without a binder, polyvinylpyrrolidone (PVP) was conducted. Effects of co-milling on binder function and flowability of the powder blend was also investigated. Flakes were comminuted, and the size and size distribution, friability, Hausner ratio, and Carr index of the granulations were determined. Crude herb should be reduced to a suitable size for it to be successfully roller compacted. Larger-sized and less friable granules were obtained with decreasing roller speed. Addition of PVP affected the flowability and binding capacity of the herbal powder blend, which influenced size and friability of the granules. Co-milling of PVP with the herbal powder enhanced the flow of the blends and the effectiveness of the binder, which contributed favorably to the roller-compacted product. Roller compaction is a convenient and cost-effective granulating technique suitable for milled botanicals. Co-milling can be used to improve the properties of roller-compacted products.|
|Source Title:||Pharmaceutical Development and Technology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 15, 2018
WEB OF SCIENCETM
checked on Jul 23, 2018
checked on Aug 10, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.