Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106277
Title: Quantification of the surface morphologies of lactose carriers and their effect on the in vitro deposition of salbutamol sulphate
Authors: Heng, P.W.S. 
Chan, L.W. 
Lim, L.T. 
Keywords: Lactose carrier
Salbutamol sulphate
Scanning probe microscopy
Surface roughness
Twin impinger
Issue Date: Mar-2000
Citation: Heng, P.W.S.,Chan, L.W.,Lim, L.T. (2000-03). Quantification of the surface morphologies of lactose carriers and their effect on the in vitro deposition of salbutamol sulphate. Chemical and Pharmaceutical Bulletin 48 (3) : 393-398. ScholarBank@NUS Repository.
Abstract: Application of the scanning probe microscopy technique for quantitative measurement of the surface roughness of lactose carriers was evaluated. The roughness values of four different lactose carriers were related to the in vitro deposition results of the drug, salbutamol sulphate. The rugosity values of the lactose carriers were represented by Ra values which were in the order of DCL-40>DCL-11>lactose 325M>lactose 200 M. In vitro deposition results using a twin impinger showed that rougher carrier surfaces generally allowed more drug particles to be emitted from the capsules and inhaler but the availability of the drug to stage 2 was reduced, as detachment of drug particles from the carrier surfaces was more hindered. There was an optimum Ra value for greater delivery of the drug particles to stage 2 of the twin impinger. A balance between adherence and detachment of the drug from the carrier surface was needed in order to optimize the delivery of a drug to the desired target sites using a dry powder inhaler.
Source Title: Chemical and Pharmaceutical Bulletin
URI: http://scholarbank.nus.edu.sg/handle/10635/106277
ISSN: 00092363
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

40
checked on Oct 12, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.