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Title: Production of alginate microspheres by internal gelation using an emulsification method
Authors: Chan, L.W. 
Lee, H.Y.
Heng, P.W.S. 
Keywords: Alginate
Internal gelation
Issue Date: 21-Aug-2002
Citation: Chan, L.W., Lee, H.Y., Heng, P.W.S. (2002-08-21). Production of alginate microspheres by internal gelation using an emulsification method. International Journal of Pharmaceutics 242 (1-2) : 259-262. ScholarBank@NUS Repository.
Abstract: Alginate is a natural polysaccharide found in brown algae. Alginates are widely used in the food and pharmaceutical industries and have been employed as a matrix for the entrapment of drugs, macromolecules and biological cells. Alginate microspheres can be produced by the external or internal gelation method using calcium salts. The addition of calcium chloride solution in the final phase of production of microspheres by external gelation method using an emulsification technique causes the disruption of the equilibrium of the system being stirred, resulting in a significant degree of clumping of microspheres. Therefore, in this study, production of alginate microspheres by the internal gelation method using a modified emulsification technique was explored. The influence of calcium salt, added in varying amounts and at different stages, on the morphology of the microspheres was investigated. The effects of other hardening agents and different drying methods were also studied. © 2002 Published by Elsevier Science B.V.
Source Title: International Journal of Pharmaceutics
ISSN: 03785173
DOI: 10.1016/S0378-5173(02)00170-9
Appears in Collections:Staff Publications

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