Please use this identifier to cite or link to this item: https://doi.org/10.1002/jps.20092
Title: Preparation of tributyrin emulsion and characterization of the binding of the emulsion particles to low-density lipoprotein in vitro
Authors: Su, J.
Ho, P.C. 
Keywords: Emulsion
Interaction
Lipoprotein
Phospholipid
Tributyrin
Issue Date: Jul-2004
Citation: Su, J., Ho, P.C. (2004-07). Preparation of tributyrin emulsion and characterization of the binding of the emulsion particles to low-density lipoprotein in vitro. Journal of Pharmaceutical Sciences 93 (7) : 1755-1765. ScholarBank@NUS Repository. https://doi.org/10.1002/jps.20092
Abstract: Tributyrin has been shown to be an effective antitumor agent alone or in combination with other chemotherapeutic agents in vitro. Because tributyrin exists as an oil, it could be formulated as an emulsion to facilitate its delivery. The aim of this study was to develop a tributyrin emulsion with affinity to low-density lipoprotein (LDL). The tributyrin emulsion was prepared by sonication. Sizes of the different fractions of the emulsion particles separated by ultracentrifugation were determined. Cholesterol was found to decrease the particle size slightly because of its condensing effect. The emulsion monolayer prepared was proved to bind effectively with LDL in vitro. The dissociation constant and binding maximum to LDL of the emulsion fraction 1 with smaller particle sizes were 0.1236 μM and 0.4140 mmol/mol, and that of the fraction 2 with larger particle sizes were 0.0635 μM and 0.2654 mmol/mol, respectively. These results suggested that the binding ability of tributyrin emulsion depended on the component of the monolayer as well as the size of the emulsion particles. The potential pharmaceutical applications of this tributyrin emulsion are discussed. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association.
Source Title: Journal of Pharmaceutical Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/106253
ISSN: 00223549
DOI: 10.1002/jps.20092
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