Please use this identifier to cite or link to this item:
|Title:||Preparation of tributyrin emulsion and characterization of the binding of the emulsion particles to low-density lipoprotein in vitro|
|Citation:||Su, J., Ho, P.C. (2004-07). Preparation of tributyrin emulsion and characterization of the binding of the emulsion particles to low-density lipoprotein in vitro. Journal of Pharmaceutical Sciences 93 (7) : 1755-1765. ScholarBank@NUS Repository. https://doi.org/10.1002/jps.20092|
|Abstract:||Tributyrin has been shown to be an effective antitumor agent alone or in combination with other chemotherapeutic agents in vitro. Because tributyrin exists as an oil, it could be formulated as an emulsion to facilitate its delivery. The aim of this study was to develop a tributyrin emulsion with affinity to low-density lipoprotein (LDL). The tributyrin emulsion was prepared by sonication. Sizes of the different fractions of the emulsion particles separated by ultracentrifugation were determined. Cholesterol was found to decrease the particle size slightly because of its condensing effect. The emulsion monolayer prepared was proved to bind effectively with LDL in vitro. The dissociation constant and binding maximum to LDL of the emulsion fraction 1 with smaller particle sizes were 0.1236 μM and 0.4140 mmol/mol, and that of the fraction 2 with larger particle sizes were 0.0635 μM and 0.2654 mmol/mol, respectively. These results suggested that the binding ability of tributyrin emulsion depended on the component of the monolayer as well as the size of the emulsion particles. The potential pharmaceutical applications of this tributyrin emulsion are discussed. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association.|
|Source Title:||Journal of Pharmaceutical Sciences|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 13, 2019
WEB OF SCIENCETM
checked on Feb 4, 2019
checked on Dec 28, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.