Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106230
Title: Population pharmacokinetics of phenytoin in Singapore Chinese
Authors: Chan, E. 
Ti, T.Y.
Lee, H.S.
Keywords: children and adults
Chinese epileptics
pharmacogenetics
Phenytoin
population pharmacokinetics
Issue Date: Aug-1990
Citation: Chan, E., Ti, T.Y., Lee, H.S. (1990-08). Population pharmacokinetics of phenytoin in Singapore Chinese. European Journal of Clinical Pharmacology 39 (2) : 177-181. ScholarBank@NUS Repository.
Abstract: The pharmacokinetics of phenytoin was studied in 66 epileptic Chinese children and adults. The data were analysed by the population approach, using the non-linear mixed effect model, in the MULTI (ELS) program. There was no age or gender-related effect on either the apparent maximum elimination rate (kmax) or Michaelis-Menten constant (KM). Kmax was related to body weight 0.656. The population pharmacokinetics was similar in children and adults. Kmax and KM were estimated to be 30.72 mg·kg-0.656 day-1 and 2.307 mg·l-1, respectively. Kmax was higher than reported values, and KM was comparable to that reported in a study in Japanese, but was much lower than that reported in studies of European patients. The inter-individual variability of KM (CV 65.58%) was substantially higher than that of kmax (CV 28.49%), and the residual (intra-individual) variability was found 21.33% (CV). © 1990 Springer-Verlag.
Source Title: European Journal of Clinical Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/106230
ISSN: 00316970
Appears in Collections:Staff Publications

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