Please use this identifier to cite or link to this item: https://doi.org/10.2147/IJN.S26538
Title: Perorally active nanomicellar formulation of quercetin in the treatment of lung cancer
Authors: Tan, B.-J. 
Liu, Y.
Chang, K.-L.
Lim, B.K.W.
Chiu, G.N.C. 
Keywords: Lung cancer
PEG-PE
Peroral drug delivery
Polymeric micelles
Quercetin
Issue Date: 2012
Citation: Tan, B.-J., Liu, Y., Chang, K.-L., Lim, B.K.W., Chiu, G.N.C. (2012). Perorally active nanomicellar formulation of quercetin in the treatment of lung cancer. International Journal of Nanomedicine 7 : 651-661. ScholarBank@NUS Repository. https://doi.org/10.2147/IJN.S26538
Abstract: Background: Realizing the therapeutic benefits of quercetin is mostly hampered by its low water solubility and poor absorption. In light of the advantages of nanovehicles in the delivery of flavanoids, we aimed to deliver quercetin perorally with nanomicelles made from the diblock copolymer, polyethylene glycol (PEG)-derivatized phosphatidylethanolamine (PE). Methods: Quercetin-loaded nanomicelles were prepared by using the film casting method, and were evaluated in terms of drug incorporation efficiency, micelle size, interaction with Caco-2 cells, and anticancer activity in the A549 lung cancer cell line and murine xenograft model. Results: The incorporation efficiency into the nanomicelles was ≥88.9% when the content of quercetin was up to 4% w/w, with sizes of 15.4-18.5 nm and polydispersity indices of
Source Title: International Journal of Nanomedicine
URI: http://scholarbank.nus.edu.sg/handle/10635/106201
ISSN: 11769114
DOI: 10.2147/IJN.S26538
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