Please use this identifier to cite or link to this item: https://doi.org/10.1080/10837450500464123
Title: New indices to characterize powder flow based on their avalanching behavior
Authors: Soh, J.L.P.
Liew, C.V. 
Heng, P.W.S. 
Keywords: Avalanche flow
Avalanche flow index
Cohesive interaction index
Powder flow
Preformulation
Issue Date: Feb-2006
Citation: Soh, J.L.P., Liew, C.V., Heng, P.W.S. (2006-02). New indices to characterize powder flow based on their avalanching behavior. Pharmaceutical Development and Technology 11 (1) : 93-102. ScholarBank@NUS Repository. https://doi.org/10.1080/10837450500464123
Abstract: Use of powder avalanches in the study of flow properties of pharmaceutical excipients has yet to be popularized even though it is rather simple to use and yields comparatively reliable results. Commonly employed flow assessment methods include compressibility studies and shear cell and repose angle measurements. Though widely accepted, these methods are not without limitations and inadequacies. More often than not, experimental and environmental conditions lead to a considerable amount of variability in the results obtained. The primary objective of this current work is to propose two new indices, avalanche flow index (AFI) and cohesive interaction index (CoI) based on the avalanche flow behaviors of powders. Not only were these two indices able to describe the ease of powder flow but they also provided a simpler means of quantifying the extent of cohesive interactions within the powder mass without elaborate mathematical functions. Copyright © Taylor & Francis Group, LLC.
Source Title: Pharmaceutical Development and Technology
URI: http://scholarbank.nus.edu.sg/handle/10635/106169
ISSN: 10837450
DOI: 10.1080/10837450500464123
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